AZ-3
Product Specifications
UNSPSC Description
AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ-3.html
Solubility
10 mM in DMSO
Smiles
FC1=NC=C(N2C[C@H]3N(C)C[C@@H]2C3)C=C1NC4=NC(N[C@@H](CC)C)=C(C)C=N4
Molecular Weight
385.48
References & Citations
[1]Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61(12):5235-5244.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112442/AZ-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112442/
Clinical Information
No Development Reported
CAS Number
2228908-91-4
Curated Selection
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