Prolyl Hydroxylase inhibitor 1
Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF) -prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1].
Product Specifications
CAS Number
2205125-60-4
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Prolyl_Hydroxylase_inhibitor_1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(O)=O)C1=C(O)C=C(C2=CN(CCCC3=CC=C(Cl)C=C3)N=N2)C=N1
Molecular Formula
C19H18ClN5O4
Molecular Weight
415.83
References & Citations
[1]Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5- (1 H-1,2,3-triazol-4-yl) picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia. J Med Chem. 2018 Jun 28;61 (12) :5332-5349.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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