PI3Kdelta inhibitor 1
PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM[1].
Product Specifications
CAS Number
[2242109-74-4]
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PI3Kdelta_inhibitor_1.html
Solubility
10 mM in DMSO
Smiles
CN1C2=NC(C3=CC(NS(C)(=O)=O)=C(OC)N=C3)=CC(OC[C@H]4CN(CCC5CCOCC5)CCC4)=C2C=N1
Molecular Formula
C27H38N6O5S
Molecular Weight
558.69
References & Citations
[1]Hamajima T, et al. Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor. Bioorg Med Chem. 2018 Aug 7;26 (14) :3917-3924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kδ
Curated Selection
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