BPIQ-I

BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].

Product Specifications

CAS Number

174709-30-9

Product Name Alternative

PD 159121

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bpiq-i.html

Solubility

10 mM in DMSO

Smiles

CN1C=NC2=CC3=C(NC4=CC=CC(Br)=C4)N=CN=C3C=C21

Molecular Formula

C16H12BrN5

Molecular Weight

354.20

References & Citations

[1]Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83 (2) :99-107.|[2]Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291 (2) :F358-67.