P38 MAP Kinase Inhibitor IV
P38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1].
Product Specifications
CAS Number
[1638-41-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p38-map-kinase-inhibitor-iv.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
OC1=C(Cl)C=C(Cl)C(Cl)=C1S(=O)(C2=C(O)C(Cl)=CC(Cl)=C2Cl)=O
Molecular Formula
C12H4Cl6O4S
Molecular Weight
456.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu YC, et al. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007;352 (3) :656-661.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α; p38β; p38δ
Curated Selection
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