Syk Inhibitor II (dihydrochloride)
Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect[1].
Product Specifications
CAS Number
227449-73-2
UNSPSC
12352005
Target
5-HT Receptor; Syk
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/syk-inhibitor-ii-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl.[H]Cl
Molecular Formula
C14H17Cl2F3N6O
Molecular Weight
413.23
References & Citations
[1]Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13 (16) :4936-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MUC4
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