Safingol
Safingol is a lyso-sphingolipid PKC (protein kinase C) inhibitor[1].
Product Specifications
CAS Number
15639-50-6
Product Name Alternative
L-threo-dihydrosphingosine
UNSPSC
12352211
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/safingol.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO
Molecular Formula
C18H39NO2
Molecular Weight
301.51
References & Citations
[1]Tsukamoto S, et al. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. Mol Cancer Ther. 2015 Oct;14 (10) :2303-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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