RGB-286147

RGB-286147 is a selective and ATP-competitive CDK and CDK-related kinases (CRK) inhibitor with IC50 values ranging from 9-839 nM. RGB-286147 shows less active against other non-CDK/CRK kinases. RGB-286147 induces cell apoptosis, and exhibits anti-tumor activity[1].

Product Specifications

CAS Number

[784211-09-2]

UNSPSC

12352005

Target

Apoptosis; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rgb-286147.html

Purity

98.60

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

O=C1C2=C(N(C3=C(Cl)C=CC=C3Cl)N=C2C(C)C)N=C(CC4=CC=C(OCCO)C=C4)N1

Molecular Formula

C23H22Cl2N4O3

Molecular Weight

473.35

References & Citations

[1]Maureen Caligiuri, et al. A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol. 2005 Oct;12 (10) :1103-15.