Aloisine RP106
Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].
Product Specifications
CAS Number
496864-15-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335-H413
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aloisine-rp106.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C2=C(CCCC)C3=NC=CN=C3N2)C=C1
Molecular Formula
C17H19N3O
Molecular Weight
281.35
Precautions
P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yvette Mettey, et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46 (2) :222-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK5; GSK-3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940745-500 1x 500 µL
CD45 / LCA (2B11 + PD7/26), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471003-500 1x 500 µL
Mucin 5AC (MUC5AC) (58M1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881931-100 1x 100 µL
CD3e (T-Cell Marker) (C3e/1931), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882030-100 1x 100 µL
Catenin, beta (CTNNB1) (CTNNB1/2030R), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940091-500 1x 500 µL
Fibronectin (2755-8), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details