Aloisine RP106
Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].
Product Specifications
CAS Number
[496864-15-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335-H413
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aloisine-rp106.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C2=C(CCCC)C3=NC=CN=C3N2)C=C1
Molecular Formula
C17H19N3O
Molecular Weight
281.35
Precautions
P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yvette Mettey, et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46 (2) :222-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK5; GSK-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1083939-01 0.02 mg (E-Coli)
Recombinant Campylobacter fetus subsp. fetus Glutamyl-tRNA reductase (hemA)
Ask
View Details MBS1083939-02 0.02 mg (Yeast)
Recombinant Campylobacter fetus subsp. fetus Glutamyl-tRNA reductase (hemA)
Ask
View Details 
MBS1083939-03 0.1 mg (E-Coli)
Recombinant Campylobacter fetus subsp. fetus Glutamyl-tRNA reductase (hemA)
Ask
View Details 
MBS1083939-04 0.1 mg (Yeast)
Recombinant Campylobacter fetus subsp. fetus Glutamyl-tRNA reductase (hemA)
Ask
View Details MBS1083939-05 0.02 mg (Baculovirus)
Recombinant Campylobacter fetus subsp. fetus Glutamyl-tRNA reductase (hemA)
Ask
View Details