Lck Inhibitor III
Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC50 of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC50 of 1.270 μM[1].
Product Specifications
CAS Number
1188890-30-3
UNSPSC
12352005
Target
Interleukin Related; Src
Type
Reference compound
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lck-inhibitor-iii.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(OC)C=C1NC2=NC(N3C4=CC=CC=C4N=C3)=NC(OCCN5CCOCC5)=C2.O
Molecular Formula
C25H30N6O4
Molecular Weight
478.54
References & Citations
[1]Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck) . Bioorg Med Chem Lett. 2006 Dec 1;16 (23) :5973-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2
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