Fascaplysin

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.) . Fascaplysin has been synthesized in seven steps from indole (65% yield) . Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

Product Specifications

CAS Number

[114719-57-2]

UNSPSC

12352005

Target

Apoptosis; Autophagy; CDK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/fascaplysin.html

Purity

95.6

Solubility

10 mM in DMSO

Smiles

O=C1C2=C3NC4=C(C=CC=C4)C3=CC=[N+]2C5=C1C=CC=C5.[Cl-]

Molecular Formula

C18H11ClN2O

Molecular Weight

306.75

References & Citations

[1]BenjaminPelcman, Gordon WGribble. Total synthesis of the marine sponge pigment fascaplysin. Tetrahedron Letters. 1990, 31 (17) :2381-2384.|[2]Zhidkov ME, et al. Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues. Mar Drugs. 2019 Aug 25;17 (9) :496.