GSK-2793660 (free base)

GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC) . GSK-2793660 (free base) can be used for the research of bronchiectasis[1][2].

Product Specifications

CAS Number

[1613458-70-0]

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gsk-2793660.html

Solubility

10 mM in DMSO

Smiles

NC1(C(N[C@@H](CC)/C=C/C(N2CCC3=C2C=CC=C3)=O)=O)CCOCC1

Molecular Formula

C20H27N3O3

Molecular Weight

357.45

References & Citations

[1]Szcześniak P, et al. The Synthesis of α, α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016 Feb 5;81 (3) :1057-74.|[2]Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660) . Br J Clin Pharmacol. 2017 Dec;83 (12) :2813-2820.