BACE-1 inhibitor 1
BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC50 of 56 nM[1].
Product Specifications
CAS Number
1262858-14-9
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BACE-1_inhibitor_1.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=C(C(NC2=CC=C(F)C([C@@]3(C(F)F)N=C(N)COC3)=C2)=O)N=C1
Molecular Formula
C17H14BrF3N4O2
Molecular Weight
443.22
References & Citations
[1]Veenstra SJ, et al. Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors. Bioorg Med Chem Lett. 2018 Jul 1;28 (12) :2195-2200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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