Crozbaciclib
Crozbaciclib (CDK4/6/1 Inhibitor) is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.
Product Specifications
CAS Number
[2099128-41-1]
Product Name Alternative
CDK4/6/1 Inhibitor
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crozbaciclib.html
Purity
99.94
Solubility
1 M HCl : 25 mg/mL (ultrasonic) |DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)
Smiles
CC(C1(CCCC1)C2=CC(C3=NC(NC4=CC=C(C5CCN(C)CC5)C=N4)=NC=C3F)=C6)=NC2=C6F
Molecular Formula
C28H30F2N6
Molecular Weight
488.57
References & Citations
[1]Yin L, et al. A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy. Eur J Med Chem. 2018 Jan 20;144:1-28.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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