J9
J9 is a small molecule that reverses Dexamethasone resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone[1].
Product Specifications
CAS Number
947018-15-7
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/j9.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1
Molecular Formula
C12H12N4
Molecular Weight
212.25
References & Citations
[1]Cantley AM, et al. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL) . ACS Med Chem Lett. 2014 Apr 25;5 (7) :754-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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