GSK3395879
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4[1].
Product Specifications
CAS Number
2215852-91-6
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GSK3395879.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C#N)C=CC(O[C@@H]2[C@@](CO)(O)CN(S(C3=C(C#N)C=C(C(F)(F)F)C=C3)(=O)=O)C2)=C1
Molecular Formula
C20H15F4N3O5S
Molecular Weight
485.41
References & Citations
[1]Brnardic EJ, et al. Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4) . J Med Chem. 2018 Nov 8;61 (21) :9738-9755.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TM36310L 100 Reactions
Cytomegalovirus (CMV) TaqMan PCR Lyophilized
Sign In for Pricing
View Details 
![3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol]](https://cdn.genprice.uk/products/572/2758869375204/imageurl/trc-o870290-50mg.webp)
TRC-O870290-50MG 50 mg
3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol]
Sign In for Pricing
View Details 
RD-AGRP-Mu-01 96 Tests
Mouse Agouti Related Protein (AGRP) ELISA Kit
Sign In for Pricing
View Details