(E/Z) -ZL0420

(E/Z) -ZL0420 is a racemic compound of (Z) -ZL0420 and (E) -ZL0420 isomers. (E) -ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2[1].

Product Specifications

CAS Number

[2229039-45-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-z-zl0420.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C=C(/N=N/C3=CC(C)=C(O)C=C3N)C=C2)CC1

Molecular Formula

C16H16N4O2

Molecular Weight

296.32

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zhiqing Liu, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.