IDO1 and HDAC1 Inhibitor

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively[1].

Product Specifications

CAS Number

[2227044-16-6]

UNSPSC

12352005

Target

HDAC; Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IDO1_and_HDAC1_Inhibitor.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC(N/C(C2=NON=C2NCCNC(C3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=N/O)=CC=C1F

Molecular Formula

C25H22BrFN8O4

Molecular Weight

597.40

References & Citations

[1]Fang K, et al. Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors. ACS Med Chem Lett. 2018 Mar 26;9 (4) :312-317.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; IDO1

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