IDO1 and HDAC1 Inhibitor
IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively[1].
Product Specifications
CAS Number
[2227044-16-6]
UNSPSC
12352005
Target
HDAC; Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IDO1_and_HDAC1_Inhibitor.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC(N/C(C2=NON=C2NCCNC(C3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=N/O)=CC=C1F
Molecular Formula
C25H22BrFN8O4
Molecular Weight
597.40
References & Citations
[1]Fang K, et al. Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors. ACS Med Chem Lett. 2018 Mar 26;9 (4) :312-317.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; IDO1
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