2-Amino-6-chloro-9- (3-deoxy-3-fluoro-beta-D-ribofuranosyl) -9H-purine
Selected Variant
HY-112120
Size: 1 Each
2-Amino-6-chloro-9- (3-deoxy-3-fluoro-beta-D-ribofuranosyl) -9H-purine ((2R,3S,4S,5R) -2- (2-Amino-6-chloro-9H-purin-9-yl) -4-fluoro-5- (hydroxymethyl) tetrahydrofuran-3-ol) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
1612192-05-8
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-amino-6-chloro-9-3-deoxy-3-fluoro-beta-d-ribofuranosyl-9h-purine.html
Solubility
10 mM in DMSO
Smiles
NC(N=C1Cl)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
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