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2-Amino-6-chloro-9- (3-deoxy-3-fluoro-beta-D-ribofuranosyl) -9H-purine

Selected Variant

HY-112120

Size: 1 Each

2-Amino-6-chloro-9- (3-deoxy-3-fluoro-beta-D-ribofuranosyl) -9H-purine ((2R,3S,4S,5R) -2- (2-Amino-6-chloro-9H-purin-9-yl) -4-fluoro-5- (hydroxymethyl) tetrahydrofuran-3-ol) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Product Specifications

CAS Number

1612192-05-8

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-amino-6-chloro-9-3-deoxy-3-fluoro-beta-d-ribofuranosyl-9h-purine.html

Solubility

10 mM in DMSO

Smiles

NC(N=C1Cl)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O

Molecular Formula

C10H11ClFN5O3

Molecular Weight

303.68

References & Citations

[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Price

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