(-) -Ibuprofenamide

(-) -Ibuprofenamide is an amide proagent of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2].

Product Specifications

CAS Number

[121839-78-9]

Product Name Alternative

(R) -Ibuprofenamide

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ibuprofenamide.html

Solubility

10 mM in DMSO

Smiles

CC(C)CC1=CC=C([C@@H](C)C(N)=O)C=C1

Molecular Formula

C13H19NO

Molecular Weight

205.30

References & Citations

[1]Shanbhag VR, et al. Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity. J Pharm Sci. 1992 Feb;81 (2) :149-54.|[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.