Biotin-BS
Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].
Product Specifications
UNSPSC
12352005
Target
SNIPERs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/biotin-bs.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]([C@@H](C(N[C@@H](CC(C)C)C(NCCOCCOCCOCCOCCOCCNC(CCCC[C@H]1[C@](NC(N2)=O)([H])[C@]2([H])CS1)=O)=O)=O)O)CC3=CC=CC=C3
Molecular Formula
C38H64N6O10S
Molecular Weight
797.01
References & Citations
[1]Ohoka N, et al. SNIPER (TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017 May;108 (5) :1032-1041.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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