BzNH-BS
BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].
Product Specifications
CAS Number
2443928-42-3
UNSPSC
12352005
Target
SNIPERs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bznh-bs.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]([C@@H](C(N[C@@H](CC(C)C)C(NCCOCCOCCOCCOCCOCCNC(C1=CC=CC=C1)=O)=O)=O)O)CC2=CC=CC=C2
Molecular Formula
C35H54N4O9
Molecular Weight
674.82
References & Citations
[1]Ohoka N, et al. SNIPER (TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017 May;108 (5) :1032-1041.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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