SNIPER (TACC3) -1 (hydrochloride)

SNIPERTACC3-1 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPERTACC3-1 hydrochloride induces cancer cell death[1].

Product Specifications

UNSPSC

12352005

Target

SNIPERs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sniper-tacc3-1-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCOCCOCCNC([C@H](CC(C)C)NC([C@H]([C@@H](CC1=CC=CC=C1)N)O)=O)=O)C2=CC=C(C3=NC(CNC4=NC=CC(NCC(C)C)=N4)=CS3)C=C2.[H]Cl

Molecular Formula

C41H58ClN9O6S

Molecular Weight

840.47

References & Citations

[1]Ohoka N, et al. Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014 Nov 6;5:e1513.