SNIPER (ABL) -050
SNIPER (ABL) -050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein[1].
Product Specifications
UNSPSC
12352005
Target
Bcr-Abl; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-abl-050.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](C(C4=CC=CC=C4)C5=CC=CC=C5)NC([C@H]6N(C([C@@H](NC([C@H](C)NC)=O)C7CCCCC7)=O)CCC6)=O)=O)=O)CC3)C=C2)=O)C=C1NC8=NC=CC(C9=CC=CN=C9)=N8
Molecular Formula
C68H84N12O9
Molecular Weight
1213.47
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC403912-100 1x 100 µL
Neurofilament (H+L) (Neuronal Marker) (2F11), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
487990 100 µL
PAIP1 (Polyadenylate-Binding Protein-Interacting Protein 1, Poly (A) Binding Protein Interacting Protein 1)
Sign In for Pricing
View Details 
orb2372054 100 µL
P47/Pleckstrin Rabbit Polyclonal Antibody (APC-Cy5.5)
Sign In for Pricing
View Details