SNIPER (ABL) -050
SNIPER (ABL) -050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein[1].
Product Specifications
UNSPSC
12352005
Target
Bcr-Abl; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-abl-050.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](C(C4=CC=CC=C4)C5=CC=CC=C5)NC([C@H]6N(C([C@@H](NC([C@H](C)NC)=O)C7CCCCC7)=O)CCC6)=O)=O)=O)CC3)C=C2)=O)C=C1NC8=NC=CC(C9=CC=CN=C9)=N8
Molecular Formula
C68H84N12O9
Molecular Weight
1213.47
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
99100500 500 mL
Diethylene Glycol Monobutyl Ether 98% For Synthesis
Sign In for Pricing
View Details 
MBS637072-01 1 mg
Creatine Kinase MM Isoenzyme III, Recombinant (CKMM) (Pichia)
Sign In for Pricing
View Details