SNIPER (ABL) -050

SNIPER (ABL) -050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein[1].

Product Specifications

UNSPSC

12352005

Target

Bcr-Abl; SNIPERs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sniper-abl-050.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](C(C4=CC=CC=C4)C5=CC=CC=C5)NC([C@H]6N(C([C@@H](NC([C@H](C)NC)=O)C7CCCCC7)=O)CCC6)=O)=O)=O)CC3)C=C2)=O)C=C1NC8=NC=CC(C9=CC=CN=C9)=N8

Molecular Formula

C68H84N12O9

Molecular Weight

1213.47

References & Citations

[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.