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HG-7-85-01-Decyclopropane

HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].

Product Specifications

CAS Number

2444044-44-2

Product Name Alternative

PROTAC ABL binding moiety 3

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-abl-binding-moiety-3.html

Solubility

10 mM in DMSO

Smiles

CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC=O)S5)C=C4)=CC=C3)=O)C=C2)CC1

Molecular Formula

C28H27F3N6O2S

Molecular Weight

568.61

References & Citations

[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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