HG-7-85-01-Decyclopropane
HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].
Product Specifications
CAS Number
2444044-44-2
Product Name Alternative
PROTAC ABL binding moiety 3
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-abl-binding-moiety-3.html
Solubility
10 mM in DMSO
Smiles
CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC=O)S5)C=C4)=CC=C3)=O)C=C2)CC1
Molecular Formula
C28H27F3N6O2S
Molecular Weight
568.61
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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