MV-1-NH-Me
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1].
Product Specifications
CAS Number
[2095244-62-3]
Product Name Alternative
PROTAC IAP binding moiety 2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-iap-binding-moiety-2.html
Solubility
10 mM in DMSO
Smiles
CNC([C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C4CCCCC4)=O)CCC3)=O)=O
Molecular Formula
C33H45N5O4
Molecular Weight
575.74
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IAP
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