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MV-1-NH-Me

MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1].

Product Specifications

CAS Number

2095244-62-3

Product Name Alternative

PROTAC IAP binding moiety 2

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-iap-binding-moiety-2.html

Solubility

10 mM in DMSO

Smiles

CNC([C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C4CCCCC4)=O)CCC3)=O)=O

Molecular Formula

C33H45N5O4

Molecular Weight

575.74

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IAP

Frequently Asked Questions

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