ATRA-hydroxyimino
Product Specifications
UNSPSC Description
ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells[1].
Target Antigen
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crabp-ii-ligand-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CC/C1=N\O
Molecular Weight
329.43
References & Citations
[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111839/ATRA-hydroxyimino-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111839/
Clinical Information
No Development Reported
CAS Number
135325-47-2
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