ZZW-115
ZZW-115 is a potent NUPR1 inhibitor, with a Kd of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and apoptosis. Anticancer activity[1][2].
Product Specifications
CAS Number
801991-87-7
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zzw-115.html
Purity
99.88
Solubility
10 mM in DMSO
Smiles
FC(C(C=C1N2CCCN3CCN(CCN(C)C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F
Molecular Formula
C24H31F3N4S
Molecular Weight
464.59
References & Citations
[1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129 (6) :2500-2513. Published 2019 Mar 28.|[2]Santofimia-Castaño P, et al. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells. 2019;8 (11) :1453. Published 2019 Nov 17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Research Square Preprint. 2024 Feb 20.|BMC Med. 2022 Oct 19;20 (1) :365.|J Cell Mol Med. 2025 Apr;29 (7) :e70519.|Mol Cancer. 2024 May 28;23 (1) :113.
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