P2Y12 antagonist 2

P2Y12 antagonist 2 is a potent P2Y12 receptor antagonist. P2Y12 antagonist 2 exhibits excellent antiplatelet aggregation potency with an IC50 value of 2.94 μM as well as antithrombotic efficacy in a rat ferric chloride model. P2Y12 antagonist 2 shows a superior safety profile than Clopidogrel (HY-15283) in a rat tail-bleeding model. P2Y12 antagonist 2 can be used to research thromboembolic disorders[1].

Product Specifications

CAS Number

[2299200-91-0]

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Oral_antiplatelet_agent_1.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1)C2=C1N=C(N3CCC(C(NS(CC4=CC=C(C)C=C4)(=O)=O)=O)(C)CC3)C(C#N)=C2

Molecular Formula

C23H24N4O5S

Molecular Weight

468.53

References & Citations

[1]Kong D, et al. Optimization of P2Y12 Antagonist Ethyl 6- (4- ((Benzylsulfonyl) carbamoyl) piperidin-1-yl) -5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. J Med Chem. 2019 Mar 28;62 (6) :3088-3106.