JAK-IN-4
JAK-IN-4 is a proagent of a JAK inhibitor, effective in murine collagen induced arthritis model[1].
Product Specifications
CAS Number
[1400877-37-3]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/JAK-IN-4.html
Solubility
10 mM in DMSO
Smiles
O=P(OC[C@@H](NC1=C(C(N)=O)C=NN2C1=CC(C3=CC=CC=C3)=C2)[C@H](O)C)(O[Na])O[Na]
Molecular Formula
C18H19N4Na2O6P
Molecular Weight
464.32
References & Citations
[1]Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10 (3) :306-311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK
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