RORγt Inverse agonist 2
RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM[1].
Product Specifications
CAS Number
[1801197-92-1]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ROR_gamma_t_Inverse_agonist_2.html
Solubility
10 mM in DMSO
Smiles
FC(C(F)(F)F)(C(F)(F)F)C1=CC=C([C@]2(CN(C([C@@H]3CC[C@@H](C(O)=O)CC3)=O)CC2)S(C4=CC=C(F)C=C4)(=O)=O)C=C1
Molecular Formula
C27H25F8NO5S
Molecular Weight
627.54
References & Citations
[1]Duan JJ, et al. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl) sulfones as Selective, Orally Active RORγt Inverse Agonists. ACS Med Chem Lett. 2019 Feb 26;10 (3) :367-373.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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