J-2156

J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats[1][2].

Product Specifications

CAS Number

[848647-56-3]

UNSPSC

12352209

Hazard Statement

H315-H319-H320

Target

Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/j-2156.html

Purity

99.88

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N)[C@@H](NC([C@H](CCN)NS(C1=CC=C(C)C2=CC=CC=C21)(=O)=O)=O)CC3=CC=CC=C3

Molecular Formula

C24H28N4O4S

Molecular Weight

468.57

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Shenoy PA, et al. The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain. Front Pharmacol. 2018 May 15;9:495.|[2]Mia Engström, et al. Superagonism at the Human Somatostatin Receptor Subtype 4. J Pharmacol Exp Ther. 2005 Jan;312 (1) :332-8.