GLP-1R agonist 2

GLP-1R agonist 2 (compound 2) is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R. GLP-1R agonist 2 has the potential for research in metabolic diseases such as type 2 diabetes and obesity[1].

Product Specifications

CAS Number

[281209-71-0]

UNSPSC

12352005

Hazard Statement

H302

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glp-1r-agonist-2.html

Purity

99.94

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(C1=NC2=CC(Cl)=C(Cl)C=C2N=C1NC(C)(C)C)(C)=O

Molecular Formula

C13H15Cl2N3O2S

Molecular Weight

348.25

Precautions

H302

References & Citations

[1]Girdhar K, et al. Novel insights into the dynamics behavior of glucagon-like peptide-1 receptor with its small molecule agonists. J Biomol Struct Dyn. 2019 Sep;37 (15) :3976-3986.|[2]Knudsen LB, et al. Small-molecule agonists for the glucagon-like peptide 1 receptor. Proc Natl Acad Sci U S A. 2007 Jan 16;104 (3) :937-42.