CPUY201112

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].

Product Specifications

CAS Number

[1860793-58-3]

UNSPSC

12352005

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cpuy201112.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC2=NC(OCC)=NC=C2C1)C3=CC(C(C)C)=C(C=C3O)O

Molecular Formula

C19H23N3O4

Molecular Weight

357.40

References & Citations

[1]Xiao-Li X, et al. CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells. Sci Rep. 2016 Jan 8;6:19004.