MGV354
MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of [1][2].
Product Specifications
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sGC_activator_1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)N(C2=NC(C3=CC=CC4=C3[C@@H](NC5=CC=C(C6CCN(C(C7CC7)=O)CC6)C=C5C)CC4)=CC=C2)N=C1)O
Molecular Formula
C35H37N5O3
Molecular Weight
575.70
References & Citations
[1]Ehara T, et al. The Discovery of (S) -1- (6- (3- ((4- (1- (Cyclopropanecarbonyl) piperidin-4-yl) -2-methylphenyl) amino) -2,3-dihydro-1 H-inden-4-yl) pyridin-2-yl) -5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61 (6) :2552-2570.|[2]Stacy R, et al. A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma.Am J Ophthalmol. 2018 Aug;192:113-123.|[3]Prasanna G, et al. A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing.Invest Ophthalmol Vis Sci. 2018 Apr 1;59 (5) :1704-1716.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111516/MGV354-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111516/
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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