MGV354

MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of [1][2].

Product Specifications

UNSPSC

12352005

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sGC_activator_1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)N(C2=NC(C3=CC=CC4=C3[C@@H](NC5=CC=C(C6CCN(C(C7CC7)=O)CC6)C=C5C)CC4)=CC=C2)N=C1)O

Molecular Formula

C35H37N5O3

Molecular Weight

575.70

References & Citations

[1]Ehara T, et al. The Discovery of (S) -1- (6- (3- ((4- (1- (Cyclopropanecarbonyl) piperidin-4-yl) -2-methylphenyl) amino) -2,3-dihydro-1 H-inden-4-yl) pyridin-2-yl) -5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61 (6) :2552-2570.|[2]Stacy R, et al. A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma.Am J Ophthalmol. 2018 Aug;192:113-123.|[3]Prasanna G, et al. A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing.Invest Ophthalmol Vis Sci. 2018 Apr 1;59 (5) :1704-1716.