Aurora inhibitor 1
Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].
Product Specifications
CAS Number
2227019-45-4
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Aurora_inhibitor_1.html
Solubility
10 mM in DMSO
Smiles
CC(N=C1NC2=CC(C(C3=CC=CC=N3)NC(C)(C)C)=NS2)=CN4C1=NC=C4C5=CNN=C5
Molecular Formula
C23H25N9S
Molecular Weight
459.57
References & Citations
[1]Yu T, et al. Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor. Bioorg Med Chem Lett. 2018 May 1;28 (8) :1397-1403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B
Frequently Asked Questions
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