TRPA1 Antagonist 1
TRPA1 Antagonist 1 is a methylene phosphate proagent which converts to its active parent agent, a TRPA1 antagonist with an IC50 of 8 nM.
Product Specifications
CAS Number
[1984825-08-2]
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/TRPA1_Antagonist_1.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(S(N2[C@H](C(N(CC3=CC(C4=CN=C(C(F)(F)F)N=C4)=NC=C3F)COP(O[Na])(O[Na])=O)=O)C[C@@H](F)[C@@H]2C)(=O)=O)C=C1
Molecular Formula
C24H20F6N5Na2O7PS
Molecular Weight
713.45
References & Citations
[1]Chen H, et al. Discovery of a Potent (4 R,5 S) -4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling. J Med Chem. 2018 Apr 26;61 (8) :3641-3659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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