TRPA1 Antagonist 1
Product Specifications
UNSPSC Description
TRPA1 Antagonist 1 is a methylene phosphate proagent which converts to its active parent agent, a TRPA1 antagonist with an IC50 of 8 nM.
Target Antigen
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/TRPA1_Antagonist_1.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(S(N2[C@H](C(N(CC3=CC(C4=CN=C(C(F)(F)F)N=C4)=NC=C3F)COP(O[Na])(O[Na])=O)=O)C[C@@H](F)[C@@H]2C)(=O)=O)C=C1
Molecular Weight
713.45
References & Citations
[1]Chen H, et al. Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling. J Med Chem. 2018 Apr 26;61(8):3641-3659.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111494/TRPA1-Antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111494/
Clinical Information
No Development Reported
CAS Number
1984825-08-2
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