Para-aminoblebbistatin

Para-aminoblebbistatin is the inhibitor for myosin II. Para-aminoblebbistatin inhibits the ATPase activity of myosin II, thereby blocking the formation and contraction of the actin-myosin network. Para-aminoblebbistatin is a non-fluorescent and photostable Blebbistatin (HY-13813) derivative[1][2].

Product Specifications

CAS Number

[2097734-03-5]

UNSPSC

12352005

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Para-aminoblebbistatin.html

Purity

99.90

Solubility

DMF : 20 mg/mL (ultrasonic; warming)

Smiles

O=C1[C@@]2(O)C(N(C3=CC=C(N)C=C3)CC2)=NC4=CC=C(C)C=C41

Molecular Formula

C18H17N3O2

Molecular Weight

307.35

References & Citations

[1]Várkuti BH, et al. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci Rep. 2016 May 31;6:26141.|[2]Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53 (31) :8211-5.|[3]Gyimesi M, et al., Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183 (2) :335-346.e13.