EGFR-IN-85
Product Specifications
UNSPSC Description
EGFR-IN-85 (Compound 1) is an EGFR inhibitor. EGFR-IN-85 has IC50 value of 0.19 μM for EGFRvⅢ phosphorylation. EGFR-IN-85 can suppress EGFR signaling within tumors. EGFR-IN-85 can be used for Glioblastoma (GBM) research[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-85.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(NC2=NC=CC(N3C=CC4=C3N=CC=C4)=N2)=C(C=C1N(CCN(C)C)C)OC)C=C
Molecular Weight
486.57
References & Citations
[1]Zhao J, et al. (1h-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl-amino-phenyl--acrylamide inhibitors of egfr for use in the treatment of brain tumors. The United States, WO2022271861 A1. 2022-12-29.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111452/EGFR-IN-85-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111452/
Clinical Information
No Development Reported
CAS Number
1956378-29-2
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