EGFR-IN-85

EGFR-IN-85 (Compound 1) is an EGFR inhibitor. EGFR-IN-85 has IC50 value of 0.19 μM for EGFRvIII phosphorylation. EGFR-IN-85 can suppress EGFR signaling within tumors. EGFR-IN-85 can be used for Glioblastoma (GBM) research[1].

Product Specifications

CAS Number

[1956378-29-2]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-85.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC(NC2=NC=CC(N3C=CC4=C3N=CC=C4)=N2)=C(C=C1N(CCN(C)C)C)OC)C=C

Molecular Formula

C26H30N8O2

Molecular Weight

486.57

References & Citations

[1]Zhao J, et al. (1h-pyrrolo[2,3-b]pyridin-1-yl) pyrimidin-2-yl-amino-phenyl--acrylamide inhibitors of egfr for use in the treatment of brain tumors. The United States, WO2022271861 A1. 2022-12-29.