ODM-204
Product Specifications
UNSPSC Description
ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80 nM and 22 nM, respectively.
Target Antigen
Androgen Receptor; Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ODM-204.html
Solubility
10 mM in DMSO
Smiles
CN([C@H]1C(C)(C)CCC(N2C=CN=C2)=C1)C3=CC(C(F)(F)F)=C(C#N)C=C3
Molecular Weight
374.40
References & Citations
[1]Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760(18)30078-5.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111421/ODM-204-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111421/
Clinical Information
Phase 2
CAS Number
1642818-64-1
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