ODM-204

ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80 nM and 22 nM, respectively.

Product Specifications

CAS Number

[1642818-64-1]

UNSPSC

12352005

Target

Androgen Receptor; Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ODM-204.html

Solubility

10 mM in DMSO

Smiles

CN([C@H]1C(C)(C)CCC(N2C=CN=C2)=C1)C3=CC(C(F)(F)F)=C(C#N)C=C3

Molecular Formula

C20H21F3N4

Molecular Weight

374.40

References & Citations

[1]Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760 (18) 30078-5.