DSP-1053 (benzenesulfonate)
DSP-1053, a benzylpiperidine derivative, is a potent serotonin transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity[1].
Product Specifications
CAS Number
1176326-78-5
UNSPSC
12352005
Target
5-HT Receptor; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dsp-1053-benzenesulfonate.html
Solubility
10 mM in DMSO
Smiles
O=C1CCOC2=CC=C(CCN3CCC(CC4=CC=C(Br)C(OCCOC)=C4)CC3)C=C12.O=S(C5=CC=CC=C5)(O)=O
Molecular Formula
C32H38BrNO7S
Molecular Weight
660.62
References & Citations
[1]Yoshinaga H, et al. Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity. Bioorg Med Chem. 2018 May 1;26 (8) :1614-1627.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT1 Receptor; mLAG-3
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