GSK2973980A
GSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 3 nM.
Product Specifications
CAS Number
2219321-25-0
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/GSK2973980A.html
Solubility
10 mM in DMSO
Smiles
FC1=C(F)C=C(NC(NC2=CN=C(C3=CC(CC[C@](CC(O)=O)(CC(F)(F)F)C4=O)=C4C=C3)C=N2)=O)C=C1
Molecular Formula
C25H19F5N4O4
Molecular Weight
534.43
References & Citations
[1]Cheung M, et al. Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1. ACS Med Chem Lett. 2018 Jan 16;9 (2) :103-108.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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