WY-135
WY-135 is an ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.
Product Specifications
CAS Number
[2163060-83-9]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WY-135.html
Solubility
10 mM in DMSO
Smiles
CC(C)S(C1=C(NC2=NC(NC3=C(OC)C=C(N4C=C(CN5CCN(C)CC5)N=N4)C=C3)=NC=C2Cl)C=CC=C1)(=O)=O
Molecular Formula
C28H34ClN9O3S
Molecular Weight
612.15
References & Citations
[1]Wang Y, et al. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Eur J Med Chem. 2018 Jan 1;143:123-136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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