CHK1-IN-2
CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.
Product Specifications
CAS Number
912367-45-4
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CHK1-IN-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[C@@H]4[C@@H](C)NCCC4)N=C1
Molecular Formula
C20H22N4OS
Molecular Weight
366.48
References & Citations
[1]Yang B, et al. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J Med Chem. 2018 Feb 8;61 (3) :1061-1073.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1
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