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EBI-1051

EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM.

Product Specifications

CAS Number

1801896-05-8

UNSPSC

12352005

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/EBI-1051.html

Solubility

10 mM in DMSO

Smiles

O=C(NOC(CO)CO)C1=C(NC2=CC=C(I)C=C2F)C(F)=C3C(C=CO3)=C1

Molecular Formula

C18H15F2IN2O5

Molecular Weight

504.22

References & Citations

[1]Lu B, et al. Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold. Bioorg Med Chem. 2018 Feb 1;26 (3) :581-589.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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